ADHD Channel
Topics & Medications
Quicklinks
Related Channels
Adderall Interactions
Adderall drug interactions with other medications, such as certain antacids, MAO inhibitors, and phenobarbital, can change your body chemistry and may lead to problems. Some of these drug interactions with Adderall can increase the amount of Adderall in the blood, resulting in possible side effects, or may cause life-threatening side effects, such as very high blood pressure. Therefore, be sure to talk to your healthcare provider about any Adderall drug interactions that may apply to you.
Adderall® (amphetamine and dextroamphetamine) can potentially interact with many drugs. Some of the drugs that may lead to Adderall interactions include:
- Acetazolamide (Diamox®)
- Ammonium chloride
- Certain antacids, such as sodium bicarbonate or calcium carbonate (Tums®)
- Certain sleep medications, such as diphenhydramine (Benadryl®, Tylenol PM®)
- Chlorpromazine (Thorazine®)
- Ethosuximide (Zarontin®)
- Haloperidol (Haldol®)
- Lithium (Eskalith®, Lithobid®, Lithonate®)
- Medications for high blood pressure (see Blood Pressure Medication)
- Meperidine (Demerol®)
- Methenamine (Hiprex®, Urex®)
- MAO inhibitors, such as:
- Phenelzine (Nardil®)
- Tranylcypromine (Parnate®)
- Selegiline (Eldepryl®, Emsam®, Zelapar®)
- Isocarboxazid (Marplan®)
- Norepinephrine (Levophed®)
- Phenobarbital (Luminal®)
- Phenytoin (Dilantin®)
- Propoxyphene (Darvocet®, Darvon®)
- Reserpine
- Tricyclic antidepressants, including:
- Amitriptyline (Elavil®)
- Clomipramine (Anafranil®)
- Doxepin (Sinequan®, Silenor®)
- Imipramine (Tofranil®)
- Desipramine (Norpramin®)
- Nortriptyline (Pamelor®)
- Protriptyline (Vivactil®).
Several herbal and nutritional supplements can also interact with Adderall. Examples of these include, but are not limited to:
Written by/reviewed by: Kristi Monson, PharmD; Arthur Schoenstadt, MD
Last reviewed by: Kristi Monson, PharmD