ADHD Channel
Topics & Medications
Quicklinks
Related Channels
Dexedrine Drug Interactions
In the case of Dexedrine, drug interactions may occur when the medicine is taken with certain antacids, some sleep medications, tricyclic antidepressants, and other drugs. Examples of other drugs that may interact with Dexedrine include lithium, ethosuximide, and meperidine. Some drug interactions with Dexedrine can potentially increase your risk of side effects or decrease the effectiveness of the medications.
Dexedrine® (dextroamphetamine sulfate) can potentially interact with several drugs. Some of the drugs that may lead to Dexedrine interactions include:
- Acetazolamide (Diamox®)
- Ammonium chloride
- Certain antacids, such as sodium bicarbonate or calcium carbonate (Tums®)
- Certain sleep medications, such as diphenhydramine (Benadryl®, Tylenol PM®)
- Chlorpromazine (Thorazine®)
- Ethosuximide (Zarontin®)
- Haloperidol (Haldol®)
- Lithium (Eskalith®, Lithobid®, Lithonate®)
- Medications for high blood pressure (see Blood Pressure Medication)
- Meperidine (Demerol®)
- Methenamine (Hiprex®, Urex®)
- MAO inhibitors, such as:
- Phenelzine (Nardil®)
- Tranylcypromine (Parnate®)
- Selegiline (Eldepryl®, Emsam®, Zelapar®)
- Isocarboxazid (Marplan®)
- Norepinephrine (Levophed®)
- Phenobarbital (Luminal®)
- Phenytoin (Dilantin®)
- Propoxyphene (Darvocet®, Darvon®)
- Reserpine
- Tricyclic antidepressants, including:
- Amitriptyline (Elavil®)
- Clomipramine (Anafranil®)
- Doxepin (Sinequan®, Silenor®)
- Imipramine (Tofranil®)
- Desipramine (Norpramin®)
- Nortriptyline (Pamelor®)
- Protriptyline (Vivactil®).
Written by/reviewed by: Kristi Monson, PharmD; Arthur Schoenstadt, MD
Last reviewed by: Kristi Monson, PharmD