ADHD Home > Adderall XR Drug Interactions

Lithium (Eskalith, Lithobid, Lithonate)
Taking Adderall XR and lithium together can decrease the effectiveness of Adderall XR. Your healthcare provider may need to adjust your dose of these drugs.
 
Medications for High Blood Pressure
Taking Adderall XR and high blood pressure medication together can decrease the effectiveness of the blood pressure medication. Your healthcare provider may need to adjust your dose of these drugs.
 
Meperidine (Demerol)
Taking Adderall XR and meperidine together can cause life-threatening side effects, such as very low blood pressure. Do not take meperidine and Adderall XR together unless specifically told to do so by your healthcare provider.
 
Methenamine (Hiprex, Urex)
Taking Adderall XR and methenamine together can decrease the amount of Adderall XR in the blood, possibly making Adderall XR less effective. Your healthcare provider may need to adjust your dose of these drugs.
 
MAO Inhibitors
Taking Adderall XR and MAO inhibitors together can cause life-threatening side effects, such as very high blood pressure. Do not take Adderall XR and MAO inhibitors together unless your healthcare provider specifically instructs you to do so.
 
Norepinephrine (Levophed)
Taking Adderall XR and norepinephrine together can cause an increase in side effects, particularly increased blood pressure and heart rate. Your healthcare provider may need to adjust your dose of these drugs.
 
Phenobarbital (Luminal)
Taking Adderall XR and phenobarbital together can cause phenobarbital to be absorbed into the body more slowly, possibly making it less effective. Taking the two medications together can also cause phenobarbital to be more effective at preventing seizures. It is difficult to predict whether taking the medications together will increase or decrease the effectiveness of phenobarbital. Your healthcare provider may need to adjust your dose of these drugs.
Written by/reviewed by:
Last reviewed by: Kristi Monson, PharmD;
Last updated/reviewed:
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