ADHD Home > Adderall XR Drug Interactions
Taking Adderall XR and phenytoin together can cause phenytoin to be absorbed into the body more slowly, possibly making it less effective. Taking the two medications together can also cause phenytoin to be more effective at preventing seizures. It is difficult to predict whether taking the medications together will increase or decrease the effectiveness of phenytoin. Your healthcare provider may need to adjust your dose of these drugs.
Propoxyphene (Darvocet, Darvon)
Taking Adderall XR and very high doses of propoxyphene together can cause life-threatening side effects, such as seizures. Do not take Adderall XR and very high doses of propoxyphene together unless your healthcare provider specifically instructs you to do so.
Taking Adderall XR and reserpine together can cause a decrease in the amount of Adderall XR in the blood, possibly making Adderall XR less effective. Your healthcare provider may need to adjust your dose of these drugs.
Taking Adderall XR and tricyclic antidepressants together can change the way the brain reacts to Adderall XR, possibly causing more side effects. Your healthcare provider may need to adjust your dose of these drugs.
Herbal and/or Nutritional Supplements
Several herbal and nutritional supplements can also interact with Adderall XR. If you are taking any natural or herbal supplements, make sure to discuss this with your healthcare provider before starting Adderall XR therapy.