ADHD Home > Dexedrine Drug Interactions

Haloperidol (Haldol)
Taking Dexedrine and haloperidol together can change the way the brain reacts to Dexedrine, making Dexedrine less effective. Your healthcare provider may need to adjust your dose of these drugs.
 
Lithium (Eskalith, Lithobid, Lithonate)
Taking Dexedrine and lithium together can decrease the effectiveness of Dexedrine. Your healthcare provider may need to adjust your dose of these drugs.
 
Medications for High Blood Pressure
Taking Dexedrine and a high blood pressure medication together can decrease the effectiveness of the blood pressure medication. Your healthcare provider may need to adjust your dose of these drugs.
 
Meperidine (Demerol)
Taking Dexedrine and meperidine together can increase your risk of side effects. Your healthcare provider may need to adjust your dose of these drugs.
 
Methenamine (Hiprex, Urex)
Taking Dexedrine and methenamine together can decrease the amount of Dexedrine in the blood, possibly making Dexedrine less effective. Your healthcare provider may need to adjust your dose of these drugs.
 
MAO Inhibitors
Taking Dexedrine and MAO inhibitors together can cause life-threatening side effects, such as very high blood pressure. Do not take Dexedrine if you have taken an MAO inhibitor in the past two weeks.
 
Norepinephrine (Levophed)
Taking Dexedrine and norepinephrine together can cause an increase in side effects, particularly increased blood pressure and heart rate. Your healthcare provider may need to adjust your dose of these drugs.
 
Phenobarbital (Luminal)
Taking Dexedrine and phenobarbital together can cause phenobarbital to be absorbed into the body more slowly, possibly making it less effective. Taking the two medications together can also cause phenobarbital to be more effective at preventing seizures. It is difficult to predict whether taking the medications together will increase or decrease the effectiveness of phenobarbital. Your healthcare provider may need to adjust your dose of these drugs.
Written by/reviewed by:
Last reviewed by: Kristi Monson, PharmD;
Last updated/reviewed:
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