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Intuniv Drug Interactions Explained
The following sections explain in detail the potentially negative interactions that can occur when Intuniv is combined with any of the drugs listed above.
Alcohol or Medications That Cause Drowsiness
Combining Intuniv with alcohol or medications that cause drowsiness can lead to undesirable or even potentially dangerous side effects, such as extreme drowsiness, "passing out," or confusion. Check with your healthcare provider before taking such medications together. People should not drink alcohol while taking Intuniv.
Blood Pressure Medications
Taking Intuniv with a high blood pressure medication might increase the risk of low blood pressure. Be sure to watch for signs of this problem, such as lightheadedness, dizziness, or fainting. Intuniv should not be combined with short-acting guanfacine (Tenex®), since Intuniv is a longer-acting version of the same active ingredient.
Intuniv is metabolized by a specific liver enzyme known as CYP3A4. Some other medications (known as CYP3A4 inhibitors) slow down the activity of this enzyme, causing an increase in the level of Intuniv in the blood. This could lead to serious Intuniv side effects. Check with your healthcare provider before taking Intuniv with a CYP3A4 inhibitor.
Intuniv may increase the level of valproate medications in the bloodstream. To prevent this drug interaction from occurring, your healthcare provider may want to measure the level of valproic acid in your blood and may need to adjust the dose of your valproate medication.