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Metadate CD Interactions Explained

The following sections explain in detail the potentially negative interactions that can occur when Metadate CD is combined with any of the drugs listed above.
Metadate CD capsules normally release the medication over several hours. However, alcohol can cause most of the medication to be released right away, within the first hour. This could increase the risk of side effects initially and could decrease the effectiveness later, as the drug wears off too soon. Do not drink alcohol while taking this medication. 
Monoamine Oxidase Inhibitors
Combining Metadate CD and MAOIs can cause life-threatening side effects, such as very high blood pressure. Do not take these two drugs together unless your healthcare provider specifically tells you to do so. Do not take Metadate CD if you have taken an MAOI within the past two weeks.
If Metadate CD and pressors are taken together, this can cause an increase in side effects, particularly increased blood pressure and heart rate. Depending on your situation, your healthcare provider may need to monitor your heart rate and blood pressure closely and adjust your dose of these drugs, if necessary.
Seizure Medications
If Metadate CD and seizure medications are combined, this can increase the amount of seizure medication in your blood, which may increase your risk of side effects. Your healthcare provider may need to decrease your dose of the seizure medication to prevent this interaction from occurring.
SSRI Antidepressants
Taking Metadate CD with SSRI antidepressants can increase the amount of the antidepressant in your blood, perhaps increasing your risk of side effects. To prevent this, your healthcare provider may need to decrease your dose of the antidepressant.
Written by/reviewed by:
Last reviewed by: Kristi Monson, PharmD;
Last updated/reviewed:
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