ADHD Home > Methylin and Depression

During clinical studies on Methylin, depression was reported as a side effect. Although stimulants appear to cause depression, they are also occasionally used "off-label" to treat associated symptoms. The manufacturer of Methylin specifically warns against using the drug to treat severe depression. If you are using Methylin and depression symptoms develop, contact your healthcare provider immediately so he or she can recommend treatments.

Methylin and Depression: An Overview

Methylin® is a prescription medication used to treat attention deficit hyperactivity disorder (ADHD). It is also used to treat narcolepsy. There are currently two forms of Methylin available:
  • Methylin Chewable Tablets® (methylphenidate chewable tablets)
  • Methylin Oral Solution® (methylphenidate oral solution).
Several side effects are possible for people taking Methylin, and depression has been reported in clinical studies of methylphenidate (the active ingredient of Methylin). Interestingly, medications like Methylin are also sometimes used to help treat depression.

Methylin and Depression: Understanding Clinical Studies

Before medicines are approved, they must go through several clinical studies in which people are given a particular medicine and compared to a group of people not given the medicine. In these studies, side effects are always documented. This way, it is possible to see what side effects occur, how often they appear, and how they compare to the group not taking the medicine. Side effects are then usually separated into those that occur in more than 1 percent of people (common side effects) and those that occur in less than 1 percent of people (rare side effects).
In clinical studies, depression was a reported side effect of methylphenidate (although the specific frequency was not reported). Therefore, it is difficult to say how common it is for people taking Methylin to experience depression.
Written by/reviewed by:
Last reviewed by: Kristi Monson, PharmD;
Last updated/reviewed:
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