ADHD Home > Methylin

How Does It Work?

Although Methylin is a stimulant, it can have effects that are opposite from what would be expected of a stimulant. While stimulants (like caffeine) can cause hyperactivity, Methylin has a calming effect when used at the doses intended for ADHD treatment. While it is not known exactly how the drug achieves this effect, it is known that the medicine affects certain chemicals in the brain (see Methylphenidate and D2 Receptors).
When used to treat narcolepsy, the medication acts as a stimulant. This helps people to stay alert and awake during the day.

When and How to Take Methylin

General considerations for when and how to take Methylin include the following:
  • The short-acting versions of the drug include the chewable tablets, tablets, and oral solution (liquid). These products are usually taken by mouth two or three times daily. In most cases, the last dose should be taken before 6 p.m. (taking it later could cause difficulty sleeping).
  • The long-acting version (Methylin ER tablets) is usually taken once a day, typically in the morning.
  • Methylin chewable tablets should always be taken with a full glass of water (at least 8 ounces) after chewing them in order to prevent choking.
  • Be sure to swallow Methylin ER tablets whole; do not crush, break, or chew them.
  • You can take the medication with or without food.
  • For the medicine to work properly, it must be taken as prescribed. Methylin will not work if you stop taking it.


Written by/reviewed by:
Last reviewed by: Kristi Monson, PharmD;
Last updated/reviewed:
List of references (click here):
Other Articles in This eMedTV Presentation

Topics & Medications


Related Channels

eMedTV Links
Copyright © 2006-2020 Clinaero, Inc.

eMedTV serves only as an informational resource. This site does not dispense medical advice or advice of any kind. Site users seeking medical advice about their specific situation should consult with their own physician. Click Terms of Use for more information.

This site complies with the HONcode standard for trustworthy health information:
verify here.