Metadate CD capsules contain tiny beads that contain the medication. Thirty percent of these are immediate release beads, and the other 70 percent are extended release beads, which dissolve more slowly.
Metadate ER and Ritalin SR
These medications are equivalent and can be substituted for each other. These medications come in tablets that dissolve slowly. Because there is no "immediate release" component for these tablets, these medications may take a little longer to start working each day.
Quillivant XR is an oral suspension (a liquid). It contains about 20 percent immediate release and 80 percent extended-release methylphenidate. After a dose is taken, the medicine begins to work in about 45 minutes and continues working for up to 12 hours.
Ritalin LA capsules contain tiny beads that contain the medication. Half of these are immediate release beads, and the other half are delayed release beads, which do not dissolve until they reach the small intestine (about four hours later).
Who Makes Methylphenidate Extended Release?
Concerta is made by ALZA Corporation. Metadate CD and Metadate ER are made by UCB, Inc. Quillivant XR is made by Tris Pharma, Inc., and distributed by NextWave Pharmaceuticals, Inc., a subsidiary of Pfizer, Inc. Ritalin LA and Ritalin SR are made by Novartis Pharmaceuticals. Generic versions are made by several manufacturers.
Metadate CD [package insert]. Smyrna, GA: UCB, Inc.;2006 February.
Metadate ER [package insert]. Smyrna, GA: UCB, Inc.;2005 May.
Ritalin and Ritalin-SR [package insert]. East Hanover, NJ: Novartis Pharmaceuticals Corporation;2006 June.
Ritalin LA [package insert]. East Hanover, NJ: Novartis Pharmaceuticals Corporation;2006 February.
Food and Drug Administration, Center for Drug Evaluation and Research. Electronic orange book: approved drug products with therapeutic equivalence evaluations. FDA Web site. Available at: http://www.fda.gov/cder/ob/. Accessed January 23, 2007.
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