Metadate ER Interactions

It is possible to develop potentially negative drug interactions when certain medications are taken with Metadate ER. Interactions can cause life-threatening side effects, such as extremely high blood pressure or increased heart rate. They may also significantly increase the levels of medication in your blood. Drugs that may cause Metadate ER interactions include clonidine, tricyclic antidepressants, seizure medications, and warfarin.

Metadate ER Drug Info

An Overview of Metadate ER Interactions

Metadate ER^® (methylphenidate extended-release) can potentially interact with many medicines. Some of the drugs that may lead to Metadate ER interactions include:

Clonidine (Catapres^®)
Monoamine oxidase inhibitors (MAOIs), including:

o Isocarboxazid (Marplan^®)

o Phenelzine (Nardil^®)

o Rasagiline (Azilect^®)

o Selegiline (Eldepryl^®, Emsam^®, Zelapar^®)

o Tranylcypromine (Parnate^®)

Pressors (medications to increase blood pressure), including:

o Dopamine (Intropin^®)

o Dobutamine (Dobutrex^®)

o Epinephrine (Adrenalin Chloride^®, EpiPen^®)

o Norepinephrine (Levophed^®)

Seizure medications, such as phenobarbital (Luminal^®), phenytoin (Dilantin^®), or primidone (Mysoline^®)
Tricyclic antidepressants, including:

o Amitriptyline (Elavil^®)

o Amoxapine (Asendin^®)

o Clomipramine (Anafranil^®)

o Doxepin (Sinequan^®)

o Imipramine (Tofranil^®)

o Desipramine (Norpramin^®)

o Nortriptyline (Pamelor^®)

o Protriptyline (Vivactil^®)

o Trimipramine (Surmontil^®)

Warfarin (Coumadin^®, Jantoven^®).

(Metadate ER Interactions Continued: Page 2)