Prolixin

Prolixin is commonly prescribed for the treatment of psychotic disorders such as schizophrenia. This typical antipsychotic works by blocking or lessening the effects of dopamine in the brain, which can become elevated in people with these and other psychotic disorders. Prolixin comes in tablet, liquid, or injectable forms. Side effects include unusual body movements, muscle tension, and overactive reflexes.

 

What Is Prolixin?

Prolixin® (fluphenazine) is a prescription medicine known as a "typical antipsychotic" that has been licensed to treat psychotic disorders, such as schizophrenia.
 
(Click Prolixin Uses for more information, including possible off-label uses.)
 

Who Makes It?

Prolixin was originally manufactured by Bristol-Myers Squibb. Although brand-name Prolixin is no longer manufactured, generic versions are still available. They are made by several different companies.
 

How Does Prolixin Work?

Prolixin belongs to a group of medications called typical (or first-generation) antipsychotic medications.
 In particular, it is part of a group of medications called phenothiazines. It is not entirely known how Prolixin works. However, the drug is known to block or lessen the effects of dopamine, a chemical in the brain. Dopamine may be elevated in people with schizophrenia or other psychotic disorders.
 
However, this medication is not a cure for schizophrenia or other psychotic disorders. It only helps to control symptoms (see Symptoms of Schizophrenia).
 
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Written by/reviewed by: Kristi Monson, PharmD; Arthur Schoenstadt, MD
Last reviewed by: Kristi Monson, PharmD;