Vyvanse Drug Interactions

Haloperidol (Haldol)
Taking Vyvanse and haloperidol together can change the way the brain reacts to Vyvanse, making Vyvanse less effective. Your healthcare provider may need to adjust your dose of these drugs.
 
Lithium (Eskalith, Lithobid)
Taking Vyvanse and lithium together can decrease the effectiveness of Vyvanse. Your healthcare provider may need to adjust your dose of these drugs.
 
Medications for High Blood Pressure
Taking Vyvanse and a high blood pressure medication together can decrease the effectiveness of the blood pressure medication. Your healthcare provider may need to adjust your dose of these drugs.
 
Meperidine (Demerol)
Taking Vyvanse and meperidine together can increase your risk of side effects. Your healthcare provider may need to adjust your dose of these drugs.
 
Methenamine (Hiprex, Urex)
Taking Vyvanse and methenamine together can decrease the amount of Vyvanse in the blood, possibly making Vyvanse less effective. Your healthcare provider may need to adjust your dose of these drugs.
 
Monoamine Oxidase Inhibitors (MAOIs)
Taking Vyvanse and an MAOI together can cause life-threatening side effects, such as very high blood pressure. Do not take Vyvanse if you have taken an MAOI in the past two weeks.
 
Phenobarbital (Luminal)
Taking Vyvanse and phenobarbital together can cause phenobarbital to be absorbed into the body more slowly, possibly making it less effective. Taking the two medications together can also cause phenobarbital to be more effective at preventing seizures. It is difficult to predict whether taking the medications together will increase or decrease the effectiveness of phenobarbital. Your healthcare provider may need to adjust your dose of these drugs.
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