Vyvanse Drug Interactions

Phenytoin (Dilantin)
Taking Vyvanse and phenytoin together can cause phenytoin to be absorbed into the body more slowly, possibly making it less effective. Taking the two medications together can also cause phenytoin to be more effective at preventing seizures. It is difficult to predict whether taking the medications together will increase or decrease the effectiveness of phenytoin. Your healthcare provider may need to adjust your dose of these drugs.
 
Propoxyphene (Darvocet, Darvon)
Taking Vyvanse and very high doses of propoxyphene together can cause life-threatening side effects, such as seizures. Do not take Vyvanse and very high doses of propoxyphene together unless specifically told to do so by your healthcare provider.
 
Reserpine
Taking Vyvanse and reserpine together can decrease the amount of Vyvanse in the blood, possibly making Vyvanse less effective. Your healthcare provider may need to adjust your dose of these drugs.
 
Tricyclic Antidepressants
Taking Vyvanse and tricyclic antidepressants together can change the way the brain reacts to Vyvanse, possibly causing more side effects. Your healthcare provider may need to adjust your dose of these drugs.
 

Final Thoughts on Vyvanse Drug Interactions

It is possible that not all Vyvanse drug interactions were discussed in this article. Therefore, you should talk with your pharmacist or healthcare provider about any specific drug interactions with Vyvanse that may apply to you.
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